• CD71/TfR Polyclonal Antibody
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Upingbio

YP-Ab-14016-100UL

CD71/TfR Polyclonal Antibody

CD71/TfR Polyclonal Antibody

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  • Gene Name: TFRC
  • Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human TFRC. AA range:101-150
  • Specificity: CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71
  • Background: This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],
  • Function: function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use t
  • Species: Human
  • Range: WB;IHC;IF;ELISA
  • Protein: Transferrin receptor protein 1
  • DA: 85kD
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