• HLA-DOβ Polyclonal Antibody
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Upingbio

YP-Ab-13930-100UL

HLA-DOβ Polyclonal Antibody

HLA-DOβ Polyclonal Antibody

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  • Gene Name: HLA-DOB
  • Immunogen: The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50
  • Specificity: HLA-DOβ Polyclonal Antibody detects endogenous levels of HLA-DOβ protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: HLA-DOB; HLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB
  • Background: HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],
  • Function: function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule.,polymorphism:The following alleles of DOB are known: DOB*0101, DOB*0102, DOB*0103 and DOB*0104. The sequence shown is that of DOB*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB).,
  • Species: Human
  • Range: WB;ELISA
  • Protein: HLA class II histocompatibility antigen DO beta chain
  • DA: 30kD
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