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Upingbio
SKU:YP-Ab-13674-100UL
Smo Polyclonal Antibody
Smo Polyclonal Antibody
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- Gene Name: SMO
- Immunogen: The antiserum was produced against synthesized peptide derived from human SMO. AA range:68-117
- Specificity: Smo Polyclonal Antibody detects endogenous levels of Smo protein.
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: SMO; SMOH; Smoothened homolog; SMO; Protein Gx
- Background: The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010],
- Function: disease:Defects in SMO are involved in basal cell carcinoma (BCC).,function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,
- Species: Human;Mouse;Rat
- Range: WB;ELISA
- Protein: Smoothened homolog
- DA: 86kD
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