• Cleaved-Thrombin R (S42) Polyclonal Antibody
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Upingbio

YP-Ab-12891-100UL

Cleaved-Thrombin R (S42) Polyclonal Antibody

Cleaved-Thrombin R (S42) Polyclonal Antibody

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  • Gene Name: F2R
  • Immunogen: The antiserum was produced against synthesized peptide derived from human PAR1. AA range:23-72
  • Specificity: Cleaved-Thrombin R (S42) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin R protein resulting from cleavage adjacent to S42.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: F2R; CF2R; PAR1; TR; Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor
  • Background: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
  • Function: function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Proteinase-activated receptor 1
  • DA: 46kD
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