• NUMB Polyclonal Antibody
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Upingbio

YP-Ab-12858-100UL

NUMB Polyclonal Antibody

NUMB Polyclonal Antibody

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  • Gene Name: NUMB
  • Immunogen: Synthesized peptide derived from the Internal region of human NUMB.
  • Specificity: NUMB Polyclonal Antibody detects endogenous levels of NUMB protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: NUMB; Protein numb homolog; h-Numb; Protein S171
  • Background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
  • Function: function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.,
  • Species: Human;Mouse;Rat
  • Range: WB; IF;ELISA
  • Protein: Protein numb homolog
  • DA: 70kD
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