• APLP-1 Polyclonal Antibody
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Upingbio

YP-Ab-12849-100UL

APLP-1 Polyclonal Antibody

APLP-1 Polyclonal Antibody

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  • Gene Name: APLP1
  • Immunogen: Synthesized peptide derived from APLP-1 . at AA range: 360-440
  • Specificity: APLP-1 Polyclonal Antibody detects endogenous levels of APLP-1 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: APLP1; Amyloid-like protein 1; APLP; APLP-1
  • Background: This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
  • Function: domain:The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.,function:May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.,function:The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.,miscellaneous:Binds zinc and copper in the extracellular domain. Zinc-
  • Species: Human;Mouse
  • Range: WB;IHC;IF;ELISA
  • Protein: Amyloid-like protein 1
  • DA: 72kD
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