• Dab1 (phospho Tyr232) Polyclonal Antibody
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YP-Ab-12645-100UL

Dab1 (phospho Tyr232) Polyclonal Antibody

Dab1 (phospho Tyr232) Polyclonal Antibody

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  • Gene Name: DAB1
  • Immunogen: The antiserum was produced against synthesized peptide derived from human Dab1 around the phosphorylation site of Tyr232. AA range:199-248
  • Specificity: Phospho-Dab1 (Y232) Polyclonal Antibody detects endogenous levels of Dab1 protein only when phosphorylated at Y232.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: DAB1; Disabled homolog 1
  • Background: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008],
  • Function: domain:The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.,function:Adapter molecule functioning in neural development. May regulate SIAH1 activity.,PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.,similarity:Contains 1 PID domain.,subunit:Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.,
  • Species: Human;Mouse;Rat
  • Range: WB;IF;ELISA
  • Protein: Disabled homolog 1
  • DA: 80kD
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