• Syntenin mouse mAb
1 1

Upingbio

YP-Ab-12625-53UL

Syntenin mouse mAb

Syntenin mouse mAb

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Size
  • Reaction species: Human
  • Gene Name: sdcbp
  • Molecular weight (DA): 32kD
  • Immunogen: Purified recombinant human Syntenin protein fragments expressed in E.coli.
  • Specificity: This antibody detects endogenous levels of Syntenin and does not cross-react with related proteins.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: wb 1:1000
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: MDA-9;MDA9;Melanoma differentiation-associated protein 9;Pro-TGF-alpha cytoplasmic domain-interacting protein 18;Scaffold protein Pbp1;SDCB1_HUMAN;Sdcbp;SDCBP;ST1;SYCL; Syndecan binding protein (syntenin);Syndecan binding protein 1;Syndecan-binding protein 1;Syntenin 1;Syntenin-1;TACIP18.
  • Background: syndecan binding protein(SDCBP) Homo sapiens The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
  • Function: function:Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.,induction:By gamma interferon in melanoma cells.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 2 PDZ (DHR) domains.,subcellular location:Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Monomer and homodimer (By similarity). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TG
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