• NOSTN rabbit pAb
1 1

Upingbio

YP-Ab-12087-100UL

NOSTN rabbit pAb

NOSTN rabbit pAb

$0.00 USD
$0.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
  • Gene Name: NOSTRIN
  • Immunogen: Synthesized peptide derived from human NOSTN AA range: 309-359
  • Specificity: This antibody detects endogenous levels of NOSTN at Human/Mouse/Rat
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1：500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004],
  • Function: domain:The FCH domain is necessary for membrane targeting.,domain:The SH3 domain mediates interaction with NOS3, DNM2 and WASL.,function:Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.,similarity:Contains 1 FCH domain.,similarity:Contains 1 SH3 domain.,subcellular location:Enriched in selected actin structures.,subunit:Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1.,tissue specificity:Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).,
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: NOSTN
View full details