• SDS3 rabbit pAb
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YP-Ab-11644-100UL

SDS3 rabbit pAb

SDS3 rabbit pAb

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  • Gene Name: SUDS3 SAP45 SDS3
  • Immunogen: Synthesized peptide derived from human SDS3 AA range: 96-146
  • Specificity: This antibody detects endogenous levels of SDS3 at Human/Mouse
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000;IHC-p 1:50-300
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008],
  • Function: domain:The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Belongs to the SDS3 family.,subunit:Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2.,tissue specificity:Expressed in various cancer cell ines.
  • Species: Human; Mouse
  • Range: WB;IHC
  • Protein: SDS3
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