• SPSY rabbit pAb
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Upingbio

YP-Ab-11330-100UL

SPSY rabbit pAb

SPSY rabbit pAb

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  • Gene Name: SMS
  • Immunogen: Synthesized peptide derived from human SPSY AA range: 81-131
  • Specificity: This antibody detects endogenous levels of SPSY at Human/Mouse
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],
  • Function: catalytic activity:S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.,disease:Defects in SMS are the cause of Snyder-Robinson syndrome (SRS) [MIM:309583]; also called X-linked mental retardation Snyder-Robinson type. SRS is characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive.,domain:Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity.,function:Required for normal viability, growth and fertility.,pathway:Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1.,similarity:Belongs to
  • Species: Human; Mouse
  • Range: WB;ELISA;IHC
  • Protein: SPSY
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