• NNT-1 Polyclonal Antibody
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Upingbio

YP-Ab-10689-100UL

NNT-1 Polyclonal Antibody

NNT-1 Polyclonal Antibody

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  • Gene Name: CLCF1 BSF3 CLC NNT1
  • Immunogen: Synthetic peptide from human protein at AA range: 171-220
  • Specificity: The antibody detects endogenous NNT-1
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3;BSF-3;Novel neurotrophin-1;NNT-1)
  • Background: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin
  • Function: disease:Defects in CLCF1 are the cause of cold-induced sweating syndrome 2 (CISS2) [MIM:610313]. Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.,function:Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.,similarity:Belongs to the IL-6 superfamily.,tissue specificity:Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.,
  • Species: Human;Mouse;Rat
  • Range: IHC;IF;ELISA
  • Protein: Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)
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