• BAG3 (Phospho-Tyr457) rabbit pAb
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Upingbio

YP-Ab-10514-100UL

BAG3 (Phospho-Tyr457) rabbit pAb

BAG3 (Phospho-Tyr457) rabbit pAb

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  • Gene Name: BAG3 BIS
  • Immunogen: Synthesized peptide derived from human BAG3 (Phospho-Tyr457)
  • Specificity: This antibody detects endogenous levels of BAG3 (Phospho-Tyr457) at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.170% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
  • Background: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
  • Function: function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.,similarity:Contains 1 BAG domain.,similarity:Contains 2 WW domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds to Bcl-2 and PLC-gamma.,
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: BAG3 (Phospho-Tyr457)
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