• XRCC4 (Phospho-Ser260) rabbit pAb
1 1

Upingbio

YP-Ab-10495-100UL

XRCC4 (Phospho-Ser260) rabbit pAb

XRCC4 (Phospho-Ser260) rabbit pAb

$0.00 USD
$0.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
  • Gene Name: XRCC4
  • Immunogen: Synthesized peptide derived from human XRCC4 (Phospho-Ser260)
  • Specificity: This antibody detects endogenous levels of XRCC4 (Phospho-Ser260) at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.151% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4)
  • Background: The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015],
  • Function: function:Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.,PTM:Monoubiquitinated.,PTM:Phosphorylated by PRKDC. The phosphorylation seems not to be necessary for binding to DNA. Phosphorylation by CK2 promotes interaction with APTX.,PTM:Sumoylation at Lys-210 is required for nuclear localization and recombination efficiency. Has no effect on ubiquitination.,similarity:Belongs to the XRCC4 family.,subunit:Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dep
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: XRCC4 (Phospho-Ser260)
  • DA: 35kD
View full details