• LAB (Phospho-Tyr136) rabbit pAb
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YP-Ab-10490-100UL

LAB (Phospho-Tyr136) rabbit pAb

LAB (Phospho-Tyr136) rabbit pAb

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  • Gene Name: LAT2 LAB NTAL WBS15 WBSCR15 WBSCR5 HSPC046
  • Immunogen: Synthesized peptide derived from human LAB (Phospho-Tyr136)
  • Specificity: This antibody detects endogenous levels of LAB (Phospho-Tyr136) at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.146% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein)
  • Background: This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008],
  • Function: disease:Defects in LAT2 may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.,PTM:May be polyubiquitinated.,PTM:Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.,s
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: LAB (Phospho-Tyr136)
  • DA: 30kD
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