• p38-γ/δ (Phospho-Tyr185/182) rabbit pAb
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YP-Ab-10489-100UL

p38-γ/δ (Phospho-Tyr185/182) rabbit pAb

p38-γ/δ (Phospho-Tyr185/182) rabbit pAb

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  • Gene Name: MAPK12 ERK6 SAPK3
  • Immunogen: Synthesized peptide derived from human p38-γ/δ (Phospho-Tyr185/182)
  • Specificity: This antibody detects endogenous levels of p38-γ/δ (Phospho-Tyr185/182) at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.145% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
  • Background: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008],
  • Function: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 magnesium ions.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by phosphorylation on threonine and tyrosine.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.,PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Mitochondrial when associat
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: p38-γ/δ (Phospho-Tyr185/182)
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