• PIK3CA Phospho-Tyr317 rabbit pAb
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YP-Ab-10478-100UL

PIK3CA Phospho-Tyr317 rabbit pAb

PIK3CA Phospho-Tyr317 rabbit pAb

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  • Gene Name: PIK3CA
  • Immunogen: Synthesized peptide derived from human PIK3CA Phospho-Tyr317
  • Specificity: This antibody detects endogenous levels of PIK3CA Phospho-Tyr317 at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.133% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
  • Background: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016],
  • Function: catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,disease:Defects in PIK3CA are associated with breast cancer [MIM:114480].,disease:Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500].,disease:Defects in PIK3CA are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,disease:Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550].,disease:PI3KCA mutations affecting exons 9 and 20 display gender-and tissue-specific patterns, thus suggesting that the
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: PIK3CA Phospho-Tyr317
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