• FKHR (Phospho-Ser249) rabbit pAb
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YP-Ab-10445-100UL

FKHR (Phospho-Ser249) rabbit pAb

FKHR (Phospho-Ser249) rabbit pAb

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  • Gene Name: FOXO1 FKHR FOXO1A
  • Immunogen: Synthesized peptide derived from human FKHR (Phospho-Ser249)
  • Specificity: This antibody detects endogenous levels of FKHR (Phospho-Ser249) at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.98% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
  • Background: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008],
  • Function: disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.,function:Transcription factor.,PTM:Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:Shuttles betw
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: FKHR (Phospho-Ser249)
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