• MLKL (phospho Ser358) Polyclonal Antibody
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YP-Ab-10353-100UL

MLKL (phospho Ser358) Polyclonal Antibody

MLKL (phospho Ser358) Polyclonal Antibody

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  • Gene Name: MLKL
  • Immunogen: Synthesized peptide derived from human MLKL (phospho S358)
  • Specificity: This antibody detects endogenous phospho levels of MLKL (phospho S358) at Human, Mouse, Rat
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC 1:100-500;IF ICC 1:100-500
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Mixed lineage kinase domain-like protein
  • Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
  • Function: domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
  • Species: Human
  • Range: IHC;IF
  • Protein: MLKL (phospho S358)
  • DA: 55kD
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