• PAPAS rabbit pAb
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Upingbio

YP-Ab-09143-100UL

PAPAS rabbit pAb

PAPAS rabbit pAb

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  • Gene Name: PAPPA-AS1 DIPAS PAPPAS
  • Immunogen: Synthesized peptide derived from human PAPAS AA range: 48-98
  • Specificity: This antibody detects endogenous levels of PAPAS at Human
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1：50-200. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Function: catalytic activity:Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.,cofactor:Binds 1 zinc ion per subunit.,developmental stage:Present in serum and placenta during pregnancy; levels increase throughout pregnancy.,enzyme regulation:Inhibited by complexation with the proform of PRG2.,function:Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.,induction:By 8-bromoadenosine-3',5'-phosphate.,PTM:There appear to be no free sulfhydryl groups.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a
  • Species: Human;Rat;Mouse;
  • Range: IHC;IF
  • Protein: PAPAS
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