• PCNT Polyclonal Antibody
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Upingbio

YP-Ab-07822-100UL

PCNT Polyclonal Antibody

PCNT Polyclonal Antibody

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  • Gene Name: PCNT KIAA0402 PCNT2
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: PCNT Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1:50-300. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],
  • Function: disease:Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2) [MIM:210720]; also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence.,function:An integral component of the pericentriolar material (PCM).,subcellular location:Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization.,subunit:Interacts with PCM1. Binds calmodulin.,tissue specificity:Expressed in all tissues tested, including placenta, liver, kidney and thymus.,
  • Species: Human;Mouse
  • Range: IHC;IF
  • Protein: Pericentrin (Kendrin) (Pericentrin-B)
  • DA: 366kD
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