• PRKRA Polyclonal Antibody
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Upingbio

YP-Ab-07774-100UL

PRKRA Polyclonal Antibody

PRKRA Polyclonal Antibody

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  • Gene Name: PRKRA PACT RAX HSD-14 HSD14
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: PRKRA Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008],
  • Function: disease:Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:612067]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.,function:Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor (By similarity). Activates EIF2AK2 in absence of double stranded RNA (dsRNA).,PTM:Phosphorylated on serine.,similarity:Contains 3 DRBM (double-stranded RNA-binding) domains.,subunit:Heterodimer. Interacts with EIF2AK2 through its DRBM domains. Also able to interact with dsRNA.,
  • Species: Human;Mouse;Rat
  • Range: WB;ELISA
  • Protein: Interferon-inducible double stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Prote
  • DA: 34kD
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