• MVP Polyclonal Antibody
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Upingbio

YP-Ab-07730-100UL

MVP Polyclonal Antibody

MVP Polyclonal Antibody

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  • Gene Name: MVP LRP
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: MVP Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012],
  • Function: domain:MVP 3 mediates interaction with PTEN.,domain:MVP 4 mediates interaction with PARP4.,function:Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.,induction:Up-regulated by IFNG.,PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on Tyr residues after EGF stimulation.,similarity:Contains 9 MVP (vault) repeats.,subcellular location:5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.,subunit:The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 Mda, it consists of a dimer of half-vaults, with each half-vault co
  • Species: Human;Mouse;Rat
  • Range: WB;ELISA
  • Protein: Major vault protein (MVP) (Lung resistance-related protein)
  • DA: 98kD
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