• IRGM Polyclonal Antibody
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Upingbio

YP-Ab-07322-100UL

IRGM Polyclonal Antibody

IRGM Polyclonal Antibody

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  • Gene Name: IRGM IFI1 IRGM1 LRG47
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 101-150
  • Specificity: IRGM Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: immunity related GTPase M(IRGM) Homo sapiens This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010],
  • Function: disease:Defects in IRGM are associated with susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. CD is commonly classified as an autoimmune disease. The causal variants do not affect the protein sequence but may lie in regulatory regions and alter its expression.,function:Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.,induction:Not up-regulated by IFNG.,miscellaneous:Depletion of IRGM by siRNA favors mycobacte
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Immunity-related GTPase family M protein (EC 3.6.5.-) (Immunity-related GTPase family M protein 1) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47 homolog) (LRG-47)
  • DA: 19kD
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