• PKHA1 Polyclonal Antibody
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Upingbio

YP-Ab-07268-100UL

PKHA1 Polyclonal Antibody

PKHA1 Polyclonal Antibody

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  • Gene Name: PLEKHA1 TAPP1
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 170-250
  • Specificity: PKHA1 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010],
  • Function: domain:Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain.,function:Binds specifically to phosphatidylinositol-3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.,subunit:Binds MPDZ and PTPN13.,tissue specificity:Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1)
  • DA: 44kD
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