• TCAM2 Polyclonal Antibody
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Upingbio

YP-Ab-07029-100UL

TCAM2 Polyclonal Antibody

TCAM2 Polyclonal Antibody

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  • Gene Name: TICAM2 TIRAP3 TIRP TRAM
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: TCAM2 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004],
  • Function: domain:The TIR domain mediates the interaction with TRAF6.,function:Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.,PTM:Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.,PTM:Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.,similarity:Belongs to the EMP24/GP25L family.,similarity:Contains 1 GOLD domain.,similarity:Contains 1 TIR domain.,subcellular location:Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor doma
  • DA: 25kD
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