• ERAP2 Polyclonal Antibody
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Upingbio

YP-Ab-07016-100UL

ERAP2 Polyclonal Antibody

ERAP2 Polyclonal Antibody

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  • Gene Name: ERAP2 LRAP
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: ERAP2 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016],
  • Function: cofactor:Binds 1 zinc ion per subunit.,function:Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.,induction:By IFN-gamma.,miscellaneous:Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M1 family.,subunit:Heterodimer; with ERAP1.,tissue specificity:Ubiquitously expressed. Highly expressed in spleen and leukocytes.,
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)
  • DA: 105kD
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