• PAR10 Polyclonal Antibody
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Upingbio

YP-Ab-06997-100UL

PAR10 Polyclonal Antibody

PAR10 Polyclonal Antibody

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  • Gene Name: PARP10
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: PAR10 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008],
  • Function: catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.,PTM:Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.,similarity:Contains 1 PARP catalytic domain.,subcellular location:Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase.,subunit:Interacts with MYC.,tissue specificity:Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10)
  • DA: 112kD
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