• ING1 Polyclonal Antibody
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Upingbio

YP-Ab-06713-100UL

ING1 Polyclonal Antibody

ING1 Polyclonal Antibody

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  • Gene Name: ING1
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: ING1 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
  • Function: disease:Defects in ING1 are a cause of squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355].,function:Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.,similarity:Belongs to the ING family.,similarity:Contains 1 PHD-type zinc finger.,subunit:Interacts with TP53.,tissue specificity:Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: Inhibitor of growth protein 1
  • DA: 46kD
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