• JIP4 Polyclonal Antibody
1 1

Upingbio

YP-Ab-06461-100UL

JIP4 Polyclonal Antibody

JIP4 Polyclonal Antibody

$0.00 USD
$0.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
  • Gene Name: SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 590-670
  • Specificity: JIP4 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011],
  • Function: function:The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.,induction:Isoform 3 is increased in systemic sclerosis fibroblasts.,PTM:Phosphorylated by MAPK8 and MAPK14 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the JIP scaffold family.,subcellular location:Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.,subcellular location:Perinuclear distribution in response to stress signals such as UV radiation.,subunit:Homo-oligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8.
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper pr
  • DA: 145kD
View full details