• SFRP3 Polyclonal Antibody
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Upingbio

YP-Ab-06120-100UL

SFRP3 Polyclonal Antibody

SFRP3 Polyclonal Antibody

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  • Gene Name: FRZB FIZ FRE FRP FRZB1 SFRP3
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 150-230
  • Specificity: SFRP3 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010],
  • Function: disease:Defects in FRZB are associated with female-specific osteoarthritis (OA) susceptibility [MIM:165720]. It is the most prevalent form of arthritis and a common cause of disability.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,tissue specificity:Expressed primarily in the cartilagenous cores of the long bone during embryonic and fetal development and in the ap
  • Species: Human;Mouse
  • Range: WB;IHC;IF;ELISA
  • Protein: Secreted frizzled-related protein 3 (sFRP-3) (Frezzled) (Fritz) (Frizzled-related protein 1) (FrzB-1)
  • DA: 35kD
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