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Upingbio
SKU:YP-Ab-05871-100UL
NPL4 Polyclonal Antibody
NPL4 Polyclonal Antibody
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- Gene Name: NPLOC4 KIAA1499 NPL4
- Immunogen: Synthesized peptide derived from human protein . at AA range: 270-350
- Specificity: NPL4 Polyclonal Antibody detects endogenous levels of protein.
- Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Background: domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.,function:The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway:Protein degradation; proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the NPL4 family.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Associated with the endoplasmic reticulum and nuclear.,subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.,tissue specificity:Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.,
- Function: domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.,function:The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway:Protein degradation; proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the NPL4 family.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Associated with the endoplasmic reticulum and nuclear.,subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.,tissue specificity:Expressed at highest levels in brain, heart, skeletal muscle, kidney and
- Species: Human;Rat;Mouse
- Range: WB;ELISA
- Protein: Nuclear protein localization protein 4 homolog (Protein NPL4)
- DA: 66kD
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