• MLL2 Polyclonal Antibody
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YP-Ab-05767-100UL

MLL2 Polyclonal Antibody

MLL2 Polyclonal Antibody

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  • Gene Name: MLL2 ALR KMT2D MLL4
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 1430-1510
  • Specificity: MLL2 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1:50-300. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010],
  • Function: catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,domain:LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor.,function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.,miscellaneous:This gene mapped to a chromosomal region involved in duplications and translocations associated with cancer.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.,similarity:Contains 1 post-SET domain.,similarity:Contai
  • Species: Human;Rat;Mouse;
  • Range: IHC;IF
  • Protein: Histone-lysine N-methyltransferase MLL2 (EC 2.1.1.43) (ALL1-related protein) (Lysine N-methyltransferase 2D) (KMT2D) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
  • DA: 609kD
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