• LRBA Polyclonal Antibody
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Upingbio

YP-Ab-05695-100UL

LRBA Polyclonal Antibody

LRBA Polyclonal Antibody

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  • Gene Name: LRBA BGL CDC4L LBA
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 1970-2050
  • Specificity: LRBA Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1:50-300. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
  • Function: caution:Was originally (PubMed:1505956) said to be similar to yeast CDC4, but that similarity is very limited.,induction:By lipopolysaccharide (LPS).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 BEACH domain.,similarity:Contains 6 WD repeats.,
  • Species: Human;Mouse
  • Range: IHC;IF
  • Protein: Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)
  • DA: 314kD
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