• GPSM2 Polyclonal Antibody
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Upingbio

YP-Ab-05608-100UL

GPSM2 Polyclonal Antibody

GPSM2 Polyclonal Antibody

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  • Gene Name: GPSM2 LGN
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: GPSM2 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
  • Function: function:Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.,miscellaneous:Dysfunction of LGN is associated with the phenotype of multiple micronuclei due to chromosomal mis-segregation and defect in cell division through mis-localization of mitotic splindle regulator protein NuMA.,similarity:Belongs to the GPSM family.,similarity:Contains 4 GoLoco domains.,similarity:Contains 8 TPR repeats.,subcellular location:Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.,subunit:Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2.,tissue specificity:Ubiquitously expressed.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: G-protein-signaling modulator 2 (Mosaic protein LGN)
  • DA: 75kD
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