• TRAF7 Polyclonal Antibody
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Upingbio

YP-Ab-05563-100UL

TRAF7 Polyclonal Antibody

TRAF7 Polyclonal Antibody

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  • Gene Name: TRAF7 RFWD1 RNF119
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: TRAF7 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: TNF receptor associated factor 7(TRAF7) Homo sapiens Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004],
  • Function: function:E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated by MAP3K3.,PTM:Ubiquitinates itself upon phosphorylation.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 TRAF-type zinc finger.,similarity:Contains 7 WD repeats.,subcellular location:Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.,subunit:Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.,tissue specificity:Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7)
  • DA: 73kD
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