• PDS5B Polyclonal Antibody
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Upingbio

YP-Ab-05316-100UL

PDS5B Polyclonal Antibody

PDS5B Polyclonal Antibody

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  • Gene Name: PDS5B APRIN AS3 KIAA0979
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 90-170
  • Specificity: PDS5B Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: PDS5 cohesin associated factor B(PDS5B) Homo sapiens This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015],
  • Function: disease:Defects in PDS5B may be the cause of some cancers including esophageal cancer.,function:Plays a role in androgen-induced proliferative arrest in prostate cells. Required for maintenance of sister chromatid cohesion during mitosis.,induction:By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PDS5 family.,similarity:Contains 1 HEAT repeat.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with the cohesin complex.,tissue specificity:Widely expressed.,
  • Species: Human;Mouse;Rat
  • Range: WB;ELISA
  • Protein: Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)
  • DA: 159kD
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