• AVR2B Polyclonal Antibody
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Upingbio

YP-Ab-05269-100UL

AVR2B Polyclonal Antibody

AVR2B Polyclonal Antibody

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  • Gene Name: ACVR2B
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 40-120
  • Specificity: AVR2B Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Th
  • Function: catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in ACVR2B are a cause of left-right axis malformations [MIM:602730]. Th effect is due to the loss of normal left-right asymmetry. Complete left-right asymmetry reversal imparts no deleterious consequences to the affected individual, whereas randomization typically results in complex, often lethal heart malformations as well as abdominal abnormalities.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
  • Species: Human;Mouse;Rat
  • Range: WB;ELISA
  • Protein: Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
  • DA: 56kD
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