• KDM5A Polyclonal Antibody
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Upingbio

YP-Ab-05113-100UL

KDM5A Polyclonal Antibody

KDM5A Polyclonal Antibody

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  • Gene Name: KDM5A JARID1A RBBP2 RBP2
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 720-800
  • Specificity: KDM5A Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013],
  • Function: cofactor:Fe(2+).,function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 3 PHD-type zinc fingers.,subunit:Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: Lysine-specific demethylase 5A (EC 1.14.11.-) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2)
  • DA: 185kD
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