• Cofilin Mouse mAb(Mix-mA)
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Upingbio

YP-Ab-04829-53UL

Cofilin Mouse mAb(Mix-mA)

Cofilin Mouse mAb(Mix-mA)

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Size
  • Reaction species: Human; Mouse;Rat
  • Gene Name: CFL1 CFL
  • Protein name: Cofilin
  • Molecular weight (DA): 19kD
  • Immunogen: Synthesized peptide derived from human Cofilin
  • Specificity: This antibody detects endogenous levels of Cofilin at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.71% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: IHC-p1:50-200 ,WB 1:1000-2000
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
  • Background: cofilin 1(CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004],
  • Function: function:Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.,online information:Cofilin entry,PTM:Phosphorylated on Ser-3 in resting cells.,similarity:Belongs to the actin-binding proteins ADF family.,similarity:Contains 1 ADF-H domain.,subcellular location:Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.,tissue specificity:Widely distributed in various tissues.,
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