• AMPKβ2 Mouse mAb(Mix-mA)
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Upingbio

YP-Ab-04801-53UL

AMPKβ2 Mouse mAb(Mix-mA)

AMPKβ2 Mouse mAb(Mix-mA)

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Size
  • Reaction species: Human; Mouse;Rat
  • Gene Name: PRKAB2
  • Protein name: AMPKβ2
  • Molecular weight (DA): 30kD
  • Immunogen: Synthesized peptide derived from human AMPKβ2
  • Specificity: This antibody detects endogenous levels of AMPKβ2 at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.42% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: IHC-p1:50-200 ,WB 1:1000-2000
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)
  • Background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
  • Function: function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.,PTM:Phosphorylated when associated with the catalytic subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits.,
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