• HSC70 Mouse mAb(7G12)
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Upingbio

YP-Ab-04795-53UL

HSC70 Mouse mAb(7G12)

HSC70 Mouse mAb(7G12)

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  • Reaction species: Human; Mouse;Rat
  • Gene Name: HSPA8 HSC70 HSP73 HSPA10
  • Protein name: HSC70
  • Molecular weight (DA): 73kD
  • Immunogen: Synthesized peptide derived from human HSC70
  • Specificity: This antibody detects endogenous levels of HSC70 at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.34% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: IHC-p1:50-200 ,WB 1:1000-2000
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)
  • Background: This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
  • Function: function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,
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