• Toll-like Receptor 3 mouse mAb
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Upingbio

YP-Ab-04511-53UL

Toll-like Receptor 3 mouse mAb

Toll-like Receptor 3 mouse mAb

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  • Reaction species: Transfected
  • Gene Name: tlr3
  • Immunogen: Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.
  • Specificity: Transfected Only.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Monoclonal, Mouse
  • Dilution ratio: wb dilution 1:1000
  • Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
  • Concentration: mg/ml
  • Storage: -20°C/1 year
  • Other Names: CD283 ; CD283 antigen ; IIAE2 ; TLR 3 ; Tlr3 ; TLR3_HUMAN ; Toll Like Receptor 3 ; Toll-like receptor 3.
  • Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate
  • Function: disease:Defects in TLR3 are the cause of TLR3-deficient herpes simplex encephalitis (HSE) [MIM:603029]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.,disease:Genetic variation in TLR3 is associated with susceptibility to progression to geographic atrophy in age-related macular degeneration [MIM:612479]. Age-related macular degeneration (ARMD) is the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epi
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