• SDHB Polyclonal Antibody
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Upingbio

YP-Ab-04340-100UL

SDHB Polyclonal Antibody

SDHB Polyclonal Antibody

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  • Gene Name: SDHB
  • Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human SDHB. AA range:131-180
  • Specificity: SDHB Polyclonal Antibody detects endogenous levels of SDHB protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip
  • Background: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008],
  • Function: catalytic activity:Succinate + ubiquinone = fumarate + ubiquinol.,cofactor:Binds 1 2Fe-2S cluster.,cofactor:Binds 1 3Fe-4S cluster.,cofactor:Binds 1 4Fe-4S cluster.,disease:Defects in SDHB are a cause of Cowden-like syndrome [MIM:612359]. Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus.,disease:Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma [MIM:606864]; also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with inc
  • Species: Human;Mouse;Rat;Fish
  • Range: WB;IHC;IF;ELISA
  • Protein: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit mitochondrial
  • DA: 31kD
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