• CPE Polyclonal Antibody
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YP-Ab-04310-100UL

CPE Polyclonal Antibody

CPE Polyclonal Antibody

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  • Gene Name: CPE
  • Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human CPE. AA range:427-476
  • Specificity: CPE Polyclonal Antibody detects endogenous levels of CPE protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: CPE; Carboxypeptidase E; CPE; Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase
  • Background: carboxypeptidase E(CPE) Homo sapiens This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015],
  • Function: catalytic activity:Release of C-terminal arginine or lysine residues from polypeptides.,cofactor:Binds 1 zinc ion per subunit.,function:Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.,similarity:Belongs to the peptidase M14 family.,subcellular location:Secretory granules of pancreatic islets, adrenal gland, pituitary and brain.,
  • Species: Human;Mouse;Rat
  • Range: WB;IHC;IF;ELISA
  • Protein: Carboxypeptidase E
  • DA: 53kD
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