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Upingbio
SKU:YP-Ab-04298-100UL
FTO Polyclonal Antibody
FTO Polyclonal Antibody
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- Gene Name: FTO
- Immunogen: The antiserum was produced against synthesized peptide derived from human FTO. AA range:19-68
- Specificity: FTO Polyclonal Antibody detects endogenous levels of FTO protein.
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein
- Background: This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011],
- Function: function:The precise function of this protein remains to be determined.,polymorphism:At least one intronic variation within the gene predisposes to childhood and adult obesity.,similarity:Belongs to the fto family.,tissue specificity:Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.,
- Species: Human;Mouse;Rat
- Range: WB;ELISA
- Protein: Alpha-ketoglutarate-dependent dioxygenase FTO
- DA: 58kD
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