• SerpinA6 Polyclonal Antibody
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YP-Ab-04205-100UL

SerpinA6 Polyclonal Antibody

SerpinA6 Polyclonal Antibody

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  • Gene Name: SERPINA6
  • Immunogen: Synthesized peptide derived from the Internal region of human SerpinA6.
  • Specificity: SerpinA6 Polyclonal Antibody detects endogenous levels of SerpinA6 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: SERPINA6; CBG; Corticosteroid-binding globulin; CBG; Serpin A6; Transcortin
  • Background: This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008],
  • Function: disease:Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.,function:Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.,online information:Transcortin entry,PTM:Glycosylation in position Asn-260 is needed for steroid binding.,PTM:N-glycosylated; binds 5 oligosaccharide chains.,similarity:Belongs to the serpin family.,tissue specificity:Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.,
  • Species: Human;Rat;Mouse;
  • Range: IHC;IF;ELISA
  • Protein: Corticosteroid-binding globulin
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