• IFI-16 Polyclonal Antibody
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Upingbio

YP-Ab-03927-100UL

IFI-16 Polyclonal Antibody

IFI-16 Polyclonal Antibody

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  • Gene Name: IFI16
  • Immunogen: The antiserum was produced against synthesized peptide derived from human IFI16. AA range:731-780
  • Specificity: IFI-16 Polyclonal Antibody detects endogenous levels of IFI-16 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: IFI16; IFNGIP1; Gamma-interferon-inducible protein 16; Ifi-16; Interferon-inducible myeloid differentiation transcriptional activator
  • Background: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011],
  • Function: function:May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.,induction:Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. In HL-60 cells, maximum induction by gamma-interferon occurs within 12 hours whereas, for alpha-interferon, only 10-fold induction was observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3.,PTM:Isoform 3 seems to show a minor degree of complex carbohydrate addition.,PTM:Phosphorylated on Ser and Thr.,sequence caution:Intron retention.,similarity:Belongs to the HIN-200 family.,
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Gamma-interferon-inducible protein 16
  • DA: 88kD
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