• GFRP Polyclonal Antibody
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Upingbio

YP-Ab-03900-100UL

GFRP Polyclonal Antibody

GFRP Polyclonal Antibody

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  • Gene Name: GCHFR
  • Immunogen: The antiserum was produced against synthesized peptide derived from human GCHFR. AA range:31-80
  • Specificity: GFRP Polyclonal Antibody detects endogenous levels of GFRP protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: GCHFR; GFRP; GTP cyclohydrolase 1 feedback regulatory protein; GFRP; GTP cyclohydrolase I feedback regulatory protein; p35
  • Background: GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008],
  • Function: function:Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.,similarity:Belongs to the GFRP family.,subunit:Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers (By similarity). Interacts with GCH1.,tissue specificity:In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).,
  • Species: Human;Rat
  • Range: IHC;IF;ELISA
  • Protein: GTP cyclohydrolase 1 feedback regulatory protein
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