• Arrestin-β-1 (phospho Ser412) Polyclonal Antibody
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YP-Ab-03565-100UL

Arrestin-β-1 (phospho Ser412) Polyclonal Antibody

Arrestin-β-1 (phospho Ser412) Polyclonal Antibody

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  • Gene Name: ARRB1
  • Immunogen: The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412. AA range:369-418
  • Specificity: Phospho-Arrestin-β-1 (S412) Polyclonal Antibody detects endogenous levels of Arrestin-β-1 protein only when phosphorylated at S412.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1
  • Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],
  • Function: function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
  • Species: Human;Monkey
  • Range: WB;IHC;IF;ELISA
  • Protein: Beta-arrestin-1
  • DA: 47kD
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